Paediatric Dermatology Column: Review Article Neutrophilic dermatoses and the concept of autoinflammation from a paediatric perspective

Eastern Health Clinical School, Monash University, 5 Arnold St Box Hill, Victoria, 3128, Australia Neutrophilic dermatoses have primarily been classified based on their histological appearance and many have overlapping associations with systemic diseases. This article provides a brief overview of the two most common neutrophilic dermatoses, Sweet's syndrome and pyoderma gangrenosum. The clinical presentation, systemic associations, histology, treatment and the occurrence in the paediatric population of these entities are discussed. A clear understanding of the pathogenesis of these conditions remains elusive. The concept of autoinflammation is introduced, and how further investigation and knowledge of the pathways of the innate immune system may lead to the potential reclassification of neutrophilic dermatoses and more targeted treatment is discussed.